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UTI Pathogen Detection

Urinary Tract Infection is a very common bacterial or fungal infection responsible for more than 15 million office and emergency room visits each year in the United States. UTIs are more prevalent in women, older individuals, and younger individuals. Traditionally, pathogen identification in UTIs has been acomplished through culture methods which have the disadvantages of taking a long time, lack sensitivity and have been shown to miss a significant percentage of positive cases. Clio Laboratories is now offering a new solution to pathogen detection in UTIs, Real-Time Polymerase Chain Reaction (qPCR) for Urinary Tract Microbiota.

Using the latest molecular biology techniques and methods, Clio Laboratories is able to use the genetic material of the pathogen (DNA,RNA) to accurately identify the species of the pathogen and to detect resistance genes expressed by the pathogen to certain pharmacotherapies. Verification data demonstrates qPCR is over 25% more accurate when compared to traditional culture-based methods of detection.

Pathogens Detected

Bacterial

Acinetobacter baumannii

Enterobacter aerogenes

Enterococcus faecalis

Escherichia coli

Klebsiella pneumonia

Proteus mirabilis

Providencia stuartii

Staphylococcus saprophyticus

Citrobacter freundii

Enterobacter cloacae

Enterococcus faecium

Klebsiella oxytoca

Morganella morganii

Proteus vulgaris

Pseudomonas aeruginosa

Streptococcus agalactiae

Fungal

Candida albicans

Respiratory Pathogen Panel

Respiratory tract infections (RTIs) are the most common, and potentially most severe, of infections treated by health care practitioners. Lower RTIs along with influenza, are the most common cause of death by infection in the United States. Identifying the causative pathogen(s) rapidly and accurately is key in deciding on a proper treatment protocol. CLIO Laboratories’ is now offering a new solution to pathogen detection in RTls, Real-Time Polymerase Chain Reaction for Respiratory Tract Microbiota (qPCR).

Using the latest molecular biology techniques, CLIO Laboratories is able to use the genetic material of the pathogen (DNA,RNA) to accurately identify the species of the pathogen and to detect resistance genes expressed by the pathogen to certain pharmacotherapies.

Women’s Urogenital Pathogen Detection

Every year, more than one billion women in the U.S. contract urinary tract infections, vaginitis or bacterial vaginosis. The latter is fairly common (10 to 15%) for women of childbearing age and is the reason for an estimated 20 million annual medical visits. If not detected, bacterial vaginosis can cause genital tract infection and can complicate pregnancy.

When attempting to treat either a newly diagnosed or recurrent case of vaginosis or vaginitis, successful outcomes are dependent on rapidly and accurately identifying the etiological pathogen. Some microorganisms can grow very slowly in culture, can be hard to cultivate, or cannot even be cultivated when using traditional non-molecular techniques such as cultures or microscopy. These methods are subjective and can take a long time. Current culture or microscopy based methods for vaginal and urogenital microbiota investigations often provide incomplete or incorrect quantification as they can be subjective and misinterpreted. Clio Laboratories is now offering a new solution to pathogen detection in vaginosis and vaginitis, Real-Time Polymerase Chain Reaction (qPCR) for Vaginal Microbiota.

The three most common diseases included in the terms “vaginosis” and “vaginitis” are bacterial vaginosis (40%- 45%), vulvovaginal candidiasis (20%-25%), and trichomoniasis (15%- 20%). In some cases, the etiology may be mixed, and there may be more than one disease present. The most common causative agents responsible for these conditions, as well as many other commensal and pathogenic microbes (see reverse), are detected by Clio Laboratories’ qPCR testing solution for vaginal microbiota.

By providing higher sensitivity and specificity when compared to traditional culture-based methods through qPCR, Clio Laboratories is able to deliver accurate and reliable results for “ vaginosis and vaginitis diagnoses. Using the latest molecular biology techniques, Clio Laboratories is able to use the genetic material of the pathogen (DNA.RNA) to accurately identify the species of the pathogen and to detect resistance genes expressed by the pathogen to certain pharmacotherapies

Pathogens Detected

Bacterial

Atopobium vaginae

Bacteroides fragilis

BVAB2

Escherichia coli

Chlamydia trachomatis

Gardnerella vaginalis

Haemophilus ducreyi

Lactobacillus crispatus

Lactobacillus gasseri

Lactobacillus iners

Lactobacillus jensenii

Uncultured Megasphera 1

Uncultured Megasphera 2

Mobiluncus curtisii

Mobiluncus mulieris

Mycoplasma genitalium

Mycoplasma hominis

Prevotella bivia

Staphylococcus aureus

Streptococcus agalactiae (group B)

Ureaplasma urealyticum

Fungal

Candida albicans

Candida dubliniensis

Candida glabrata

Candida krusei

Candida lusitaniae

Candida parapsilosis

Candida tropicalis

Protozoal

Trichomonas vaginalis